The Histone H2B (Ac15) antibody from MyBioSource.com is a Rabbit Polyclonal antibody to H2B clustered histone 14, and H2BC14. This antibody recognizes Human antigen. The Histone H2B (Ac15) antibody has been validated for the following applications: Western Blot.
Description
Rabbit anti Human histone H2B (Ac15) antibody recognizes histone H2B when acetylated at lysine 15.
Histone H2B is one of the four core histones that make up the nucleosome core particle. Nucleosomes are the smallest subunit of chromatin and are made up of 146 bp of DNA wrapped around an octamer comprised of pairs of the four core histones (H2A, H2B, H3, and H4) (Smith, 1991). Histone H2B aids the regulation of chromatin structure and function via post-translational modifications of specialized histone variants (Molden et al. 2015). Lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene regulation. Hyperacetylation of histone tails makes chromatin more accessible to DNA-binding proteins by weakening histone-DNA and nucleosome-nucleosome interactions. Acetylation of a specific lysine residues on histones allows binding to bromine-containing domains of particular transcription and chromatin regulatory proteins (Kadiyala et al. 2012).
Wide species cross-reactivity is expected from Rabbit anti Human histone H2B (Ac15) antibody based on sequence